Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose. Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face. Granulosis rubra nasi is a rare familial disease of children, occurring on the nose, cheeks, and chin, characterized by diffuse redness, persistent excessive.

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Correspondence should be addressed to Farhana Tahseen Taj ; moc. It is an inflammatory dermatosis involving eccrine sweat glands of central face and clinically presents with hyperhidrosis, erythema, papules, pustules, and vesicles.

After having the discussion with patient, decision was made to continue Tacrolimus. As a result of persistent hyperhidrosis, diffuse erythema develops over the tip of the nose.

Folliculitis Folliculitis nares perforans Tufted folliculitis Pseudofolliculitis barbae Hidradenitis Hidradenitis suppurativa Recurrent palmoplantar hidradenitis Neutrophilic eccrine hidradenitis. Beau’s lines Yellow nail syndrome Leukonychia Azure lunula shape: The differential diagnosis like rosacea or perioral dermatitis can be considered. The skin biopsy showed dilatation of blood vessels, dilated sweat ducts with a discrete mononuclear cell infiltrate surrounding them [ Figure 3 ].

This case is being reported for its rarity since to the best of our knowledge, it has not been reported in Indian subjects so far.

Case Reports in Dermatological Medicine

It is rare with autosomal dominant or autosomal recessive pattern of inheritance. Any image downloaded must only be used for teaching purposes and not for commercial use. The authors believe that inflammation around sweat ducts are responsible for decreased sweating and hence, vesicle formation- findings in the late stage of GRN. Owing to scarcity of literature, authors could not ascertain if other authors have had similar observation of decreased sweating in late stages.


The clinical picture is characterized by hyperhidrosis of the central part of the face, most conspicuous on the tip of the nose. Pilosebaceous units are normal and no heterotopic apocrine glands are found[ 3 ] This disease usually remits after puberty, unlike the primary forms of localized hyperhidrosis but sometimes may continue into adulthood.

Small erythematous macules, papules, vesicles, or pustules lesions can also be seen [ 28 ]. Counseling the patients about the self-limiting nature of the condition is of paramount importance. G Ital Dermatol Venereol.

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Pseudopelade of Brocq Central centrifugal cicatricial alopecia Pressure alopecia Traumatic alopecia Tumor alopecia Hot comb alopecia Perifolliculitis capitis abscedens et suffodiens Graham-Little syndrome Folliculitis decalvans ungrouped: On diascopy, lesions used to disappear; however, they used to reappear after relieving the pressure.

Case Report A 20 years-old girl presented with multiple discrete asymptomatic reddish vesicles over cheeks, nose, and forehead for four years Figure 1. The histopathology report showed epidermal hyperplasia with spongiosis.

The lesions were notable for disappearance on diascopy. GRN is believed to be an inherited condition.

Lupus pernio or chilblain lupus presents with dusky papules masi plaques on the nose, toes, and fingers. Acrokeratosis paraneoplastica of Bazex Acroosteolysis Bubble hair deformity Disseminate and recurrent infundibulofolliculitis Erosive pustular dermatitis of the scalp Erythromelanosis follicularis faciei et colli Hair casts Hair follicle nevus Intermittent hair—follicle dystrophy Keratosis pilaris atropicans Kinking hair Koenen’s tumor Lichen planopilaris Lichen spinulosus Loose anagen syndrome Menkes kinky hair syndrome Monilethrix Parakeratosis pustulosa Pili Pili annulati Pili bifurcati Pili multigemini Pili pseudoannulati Pili torti Pityriasis amiantacea Plica neuropathica Poliosis Rubinstein—Taybi syndrome Setleis syndrome Traumatic anserine folliculosis Trichomegaly Trichomycosis axillaris Trichorrhexis Trichorrhexis invaginata Trichorrhexis nodosa Trichostasis spinulosa Uncombable hair syndrome Wooly hair Wooly hair nevus.


Two cases of granulosis rubra nasi in boys. With persistent hyperhidrosis, diffuse erythema develops on nose, cheeks, and chin. A biopsy of the skin lesion was done. Most of these lesions were reddish in colour and expressed small amount geanulosis serosanguineous fluid.

Granulosis rubra nasi: a rare condition treated successfully with topical tacrolimus

National Center for Biotechnology InformationU. Jorizzo Joseph, and R. No preventive measures or complications are reported and the disease has an excellent prognosis with self resolution at puberty in most cases. On examination, multiple discrete tense vesicles on an erythematous base were present over central part of face-nose, cheeks and lower part of the forehead Figure 1. Here we report a case of GRN in an adult patient with very unusual histopathological presentation. This is followed by appearance of diffuse erythema over the nose, cheeks, chin, and upper lip.

The diagnosis is largely clinical. Topical tacrolimus has been used in low dose, 0. It is commonly seen in childhood but it can present in adults.

Granulosis rubra nasi GRN is an inflammatory condition involving eccrine sweat glands of central face and clinically presents as erythema, hyperhidrosis, papules, pustules and vesicles over central face. View at Google Scholar C.

To the best of our knowledge, there are not any case reports showing GRN with sebaceous gland hyperplasia. Clinically, we made a diagnosis of Granulosis Rubra Nasi, Lymphangioma Circumscriptum, Nevus Comedonicus, and sebaceous gland hyperplasia. Saunders Elsevier publications;

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